as someone who suffers from chronic treatment resistant clinical depression from a series of motor vehicles accidents in the early 1990s, I can testify that they can make a huge difference. Are there side effect? Yes. Are there risks? Of course. Sometimes it takes experimentation because they really don’t understand how they work, and not everybody reacts the same way. I took many years of experimentation and a lot of anguish to find the right cocktail for me, but it makes a huge difference in my quality of life. Without them, I would have been dead many years ago. Would I like to get rid of them? Of course but that isn’t realistic right now.