My number one problem would be my grown child. She is always on the go. She would not be able to sit down and ride it out with the doors and windows closed and locked, which I would do. She would want to be out and about and after exposing herself, come to my place and expose me. She would want to go help others. She might even bring others to my place. She knows I have lots of stuff. She will call or text and ask about something, such as cold medication, and I can pack it up and drive to her place with it, usually without going to the store. She really has no idea of the extent of my preps, because she will still laugh about my meager preps for Y2K, laughing because it wasn't real and I was trying to prepare in case it was.
In some cases, having anti-biotics is what we would need, such as the plague, but not for everything. Unless we are one of the few who get them, or just have them, there could be a run on whatever there might be.
I think one of the first things, would be to put a sign on the front door. What would it say?