Someone posted under “covid” an article about masks causing pneumonia. The article itself was rather weak on facts. However, I was once involved in a cystic fibrosis study at Stanford University and this article rang true on several levels. The children’s center at Stanford University is the Lucile Packard Children’s Hospital where a lot of research is done.
I remember a great deal of discussion at the time about masks causing illness with children. Special masks were necessary to monitor lung capacity of children with cystic fibrosis. At the time children were getting sick with a host of respiratory issues.
With this in mind I did a little research…
Guess who co-authored an article about masks causing pneumonia during the 1918 flu pandemic… Dr. Anthony Fauci. The article appeared in a publication by the National Institute of Allergy and Infectious Diseases in the summer of 2008.
--------------------------------------------------------------------------
The title of the article at the National Institute of Health’s publication is…
Tuesday, August 19, 2008
Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic
Implications for Future Pandemic Planning
---------------------------------------------------------------------------
The full report appeared in the “Oxford Academic” - “The Journal of infectious Diseases”. A very good report…
The Journal of Infectious Diseases, Volume 198, Issue 7, 1 October 2008,
Here is their link… Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness
-------------------------------------------------------------------------------
An article about the NIH report appeared in Science Daily 20aug08. They actually interviewed Dr. Fauci… It’s here… Bacterial Pneumonia Caused Most Deaths In 1918 Influenza Pandemic
---------------------------------------------------------------------------
Here is a good article about covid and pneumonia…
What Coronavirus Does to the Lungs – John Hopkins What Coronavirus Does to the Lungs
-------------------------------------------------------------
Here is the National Institute of Health news release on the report. The pdf at the bottom is a copy of this article.
Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic
Tuesday, August 19, 2008
Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic
Implications for Future Pandemic Planning
The majority of deaths during the influenza pandemic of 1918-1919 were not caused by the influenza virus acting alone, report researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Instead, most victims succumbed to bacterial pneumonia following influenza virus infection. The pneumonia was caused when bacteria that normally inhabit the nose and throat invaded the lungs along a pathway created when the virus destroyed the cells that line the bronchial tubes and lungs.
A future influenza pandemic may unfold in a similar manner, say the NIAID authors, whose paper in the Oct. 1 issue of The Journal of Infectious Diseases is now available online. Therefore, the authors conclude, comprehensive pandemic preparations should include not only efforts to produce new or improved influenza vaccines and antiviral drugs but also provisions to stockpile antibiotics and bacterial vaccines as well.
The work presents complementary lines of evidence from the fields of pathology and history of medicine to support this conclusion. "The weight of evidence we examined from both historical and modern analyses of the 1918 influenza pandemic favors a scenario in which viral damage followed by bacterial pneumonia led to the vast majority of deaths," says co-author NIAID Director Anthony S. Fauci, M.D. "In essence, the virus landed the first blow while bacteria delivered the knockout punch."
NIAID co-author and pathologist Jeffery Taubenberger, M.D., Ph.D., examined lung tissue samples from 58 soldiers who died of influenza at various U. S. military bases in 1918 and 1919. The samples, preserved in paraffin blocks, were re-cut and stained to allow microscopic evaluation. Examination revealed a spectrum of tissue damage "ranging from changes characteristic of the primary viral pneumonia and evidence of tissue repair to evidence of severe, acute, secondary bacterial pneumonia," says Dr. Taubenberger. In most cases, he adds, the predominant disease at the time of death appeared to have been bacterial pneumonia. There also was evidence that the virus destroyed the cells lining the bronchial tubes, including cells with protective hair-like projections, or cilia. This loss made other kinds of cells throughout the entire respiratory tract — including cells deep in the lungs — vulnerable to attack by bacteria that migrated down the newly created pathway from the nose and throat.
In a quest to obtain all scientific publications reporting on the pathology and bacteriology of the 1918-1919 influenza pandemic, Dr. Taubenberger and NIAID co-author David Morens, M.D., searched bibliography sources for papers in any language. They also reviewed scientific and medical journals published in English, French and German, and located all papers reporting on autopsies conducted on influenza victims. From a pool of more than 2,000 publications that appeared between 1919 and 1929, the researchers identified 118 key autopsy series reports. In total, the autopsy series they reviewed represented 8,398 individual autopsies conducted in 15 countries.
The published reports "clearly and consistently implicated secondary bacterial pneumonia caused by common upper respiratory flora in most influenza fatalities," says Dr. Morens. Pathologists of the time, he adds, were nearly unanimous in the conviction that deaths were not caused directly by the then-unidentified influenza virus, but rather resulted from severe secondary pneumonia caused by various bacteria. Absent the secondary bacterial infections, many patients might have survived, experts at the time believed. Indeed, the availability of antibiotics during the other influenza pandemics of the 20th century, specifically those of 1957 and 1968, was probably a key factor in the lower number of worldwide deaths during those outbreaks, notes Dr. Morens.
The cause and timing of the next influenza pandemic cannot be predicted with certainty, the authors acknowledge, nor can the virulence of the pandemic influenza virus strain. However, it is possible that — as in 1918 — a similar pattern of viral damage followed by bacterial invasion could unfold, say the authors. Preparations for diagnosing, treating and preventing bacterial pneumonia should be among highest priorities in influenza pandemic planning, they write. "We are encouraged by the fact that pandemic planners are already considering and implementing some of these actions," says Dr. Fauci.
@DrPrepper @angie_nrs @Grizzleyette___Adams @Meerkat @viking @Terri9630 @UrbanHunter @VThillman @Amish Heart @Patchouli @Weedygarden @Grimm
I remember a great deal of discussion at the time about masks causing illness with children. Special masks were necessary to monitor lung capacity of children with cystic fibrosis. At the time children were getting sick with a host of respiratory issues.
With this in mind I did a little research…
Guess who co-authored an article about masks causing pneumonia during the 1918 flu pandemic… Dr. Anthony Fauci. The article appeared in a publication by the National Institute of Allergy and Infectious Diseases in the summer of 2008.
--------------------------------------------------------------------------
The title of the article at the National Institute of Health’s publication is…
Tuesday, August 19, 2008
Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic
Implications for Future Pandemic Planning
---------------------------------------------------------------------------
The full report appeared in the “Oxford Academic” - “The Journal of infectious Diseases”. A very good report…
The Journal of Infectious Diseases, Volume 198, Issue 7, 1 October 2008,
Here is their link… Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness
-------------------------------------------------------------------------------
An article about the NIH report appeared in Science Daily 20aug08. They actually interviewed Dr. Fauci… It’s here… Bacterial Pneumonia Caused Most Deaths In 1918 Influenza Pandemic
---------------------------------------------------------------------------
Here is a good article about covid and pneumonia…
What Coronavirus Does to the Lungs – John Hopkins What Coronavirus Does to the Lungs
-------------------------------------------------------------
Here is the National Institute of Health news release on the report. The pdf at the bottom is a copy of this article.
Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic
Tuesday, August 19, 2008
Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic
Implications for Future Pandemic Planning
The majority of deaths during the influenza pandemic of 1918-1919 were not caused by the influenza virus acting alone, report researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Instead, most victims succumbed to bacterial pneumonia following influenza virus infection. The pneumonia was caused when bacteria that normally inhabit the nose and throat invaded the lungs along a pathway created when the virus destroyed the cells that line the bronchial tubes and lungs.
A future influenza pandemic may unfold in a similar manner, say the NIAID authors, whose paper in the Oct. 1 issue of The Journal of Infectious Diseases is now available online. Therefore, the authors conclude, comprehensive pandemic preparations should include not only efforts to produce new or improved influenza vaccines and antiviral drugs but also provisions to stockpile antibiotics and bacterial vaccines as well.
The work presents complementary lines of evidence from the fields of pathology and history of medicine to support this conclusion. "The weight of evidence we examined from both historical and modern analyses of the 1918 influenza pandemic favors a scenario in which viral damage followed by bacterial pneumonia led to the vast majority of deaths," says co-author NIAID Director Anthony S. Fauci, M.D. "In essence, the virus landed the first blow while bacteria delivered the knockout punch."
NIAID co-author and pathologist Jeffery Taubenberger, M.D., Ph.D., examined lung tissue samples from 58 soldiers who died of influenza at various U. S. military bases in 1918 and 1919. The samples, preserved in paraffin blocks, were re-cut and stained to allow microscopic evaluation. Examination revealed a spectrum of tissue damage "ranging from changes characteristic of the primary viral pneumonia and evidence of tissue repair to evidence of severe, acute, secondary bacterial pneumonia," says Dr. Taubenberger. In most cases, he adds, the predominant disease at the time of death appeared to have been bacterial pneumonia. There also was evidence that the virus destroyed the cells lining the bronchial tubes, including cells with protective hair-like projections, or cilia. This loss made other kinds of cells throughout the entire respiratory tract — including cells deep in the lungs — vulnerable to attack by bacteria that migrated down the newly created pathway from the nose and throat.
In a quest to obtain all scientific publications reporting on the pathology and bacteriology of the 1918-1919 influenza pandemic, Dr. Taubenberger and NIAID co-author David Morens, M.D., searched bibliography sources for papers in any language. They also reviewed scientific and medical journals published in English, French and German, and located all papers reporting on autopsies conducted on influenza victims. From a pool of more than 2,000 publications that appeared between 1919 and 1929, the researchers identified 118 key autopsy series reports. In total, the autopsy series they reviewed represented 8,398 individual autopsies conducted in 15 countries.
The published reports "clearly and consistently implicated secondary bacterial pneumonia caused by common upper respiratory flora in most influenza fatalities," says Dr. Morens. Pathologists of the time, he adds, were nearly unanimous in the conviction that deaths were not caused directly by the then-unidentified influenza virus, but rather resulted from severe secondary pneumonia caused by various bacteria. Absent the secondary bacterial infections, many patients might have survived, experts at the time believed. Indeed, the availability of antibiotics during the other influenza pandemics of the 20th century, specifically those of 1957 and 1968, was probably a key factor in the lower number of worldwide deaths during those outbreaks, notes Dr. Morens.
The cause and timing of the next influenza pandemic cannot be predicted with certainty, the authors acknowledge, nor can the virulence of the pandemic influenza virus strain. However, it is possible that — as in 1918 — a similar pattern of viral damage followed by bacterial invasion could unfold, say the authors. Preparations for diagnosing, treating and preventing bacterial pneumonia should be among highest priorities in influenza pandemic planning, they write. "We are encouraged by the fact that pandemic planners are already considering and implementing some of these actions," says Dr. Fauci.
@DrPrepper @angie_nrs @Grizzleyette___Adams @Meerkat @viking @Terri9630 @UrbanHunter @VThillman @Amish Heart @Patchouli @Weedygarden @Grimm
Attachments
Last edited: